※ Sev family introduction

    SEV family contains one member in human genome, known as ROS. ROS was first indentified from a chicken genomic DNA library in 1986. Structure analysis shows that ROS consists of an extracellular domain containing a N-linked glycosidation site, a hydrophobic 24-amino acids stretch and a kinase domain. ROS gene is found to be expressed in specific tissues and the size of transcript is diverse according to different tissues, including lungs, kidneys, heart and testis. The expression pattern indicates that ROS is important for the development and mature of organs. In addition, ROS is also involved in cellular growth and differentiation. Furthermore, ROS possess the oncogenic potential and can be displayed after retrovirus transduction.(1)

Reference
1. El-Deeb, I.M., Yoo, K.H. and Lee, S.H. (2010) ROS receptor tyrosine kinase: a new potential target for anticancer drugs. Med Res Rev. PMID: 20687158