Protein Kinase Classification:      TK      Src

※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.


TK Src in eukaryotes:

Ailuropoda melanoleuca (11)Anolis carolinensis (10)Bos taurus (11)
Caenorhabditis elegans (3)Callithrix jacchus (11)Canis familiaris (10)
Cavia porcellus (11)Choloepus hoffmanni (1)Ciona intestinalis (7)
Ciona savignyi (8)Danio rerio (13)Dasypus novemcinctus (2)
Dipodomys ordii (4)Drosophila melanogaster (2)Equus caballus (11)
Erinaceus europaeus (2)Felis catus (11)Gadus morhua (8)
Gallus gallus (9)Gasterosteus aculeatus (14)Gorilla gorilla (9)
Homo sapiens (11)Ictidomys tridecemlineatus (10)Latimeria chalumnae (11)
Loxodonta africana (10)Macaca mulatta (10)Macropus eugenii (1)
Meleagris gallopavo (10)Microcebus murinus (2)Monodelphis domestica (11)
Mus musculus (11)Mustela putorius furo (11)Myotis lucifugus (10)
Nomascus leucogenys (10)Ochotona princeps (1)Oreochromis niloticus (13)
Ornithorhynchus anatinus (8)Oryctolagus cuniculus (9)Oryzias latipes (14)
Otolemur garnettii (10)Pan troglodytes (11)Pelodiscus sinensis (10)
Petromyzon marinus (8)Pongo abelii (11)Procavia capensis (4)
Pteropus vampyrus (4)Rattus norvegicus (11)Sarcophilus harrisii (10)
Sus scrofa (8)Taeniopygia guttata (10)Takifugu rubripes (13)
Tarsius syrichta (2)Tetraodon nigroviridis (15)Tupaia belangeri (1)
Tursiops truncatus (5)Vicugna pacos (3)Xenopus tropicalis (9)
Xiphophorus maculatus (14)