Kinase Classification: Asp-Based PTP CIN※ CIN family introduction CIN, also known as Chronophin, belong to Asp-Based protein phosphatase family, which use an Asp residue as a nucleophile for catalysis. CIN always colocalized with F-actin and cofilin in membrane ruffles and lmellipodia. CIN can directly dephosphorylate cofilin, and involved cofilin-dependent actin cytoskeletal reorganization. CIN plays an important role in regulating cofilin-dependent cell division and normal cytoskinesis. CIN also possesses activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP)(1).
Reference
1.Gohla, A., Birkenfeld, J. and Bokoch, G.M. (2005) Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol, 7, 21-29. PMID: 15580268
Asp-Based PTP CIN in eukaryotes:
1.Gohla, A., Birkenfeld, J. and Bokoch, G.M. (2005) Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol, 7, 21-29. PMID: 15580268
Asp-Based PTP CIN in eukaryotes:
| Ailuropoda melanoleuca (1) | Bos taurus (1) | Brachypodium distachyon (1) |
| Callithrix jacchus (1) | Canis familiaris (1) | Danio rerio (1) |
| Dipodomys ordii (1) | Equus caballus (1) | Gadus morhua (1) |
| Gallus gallus (1) | Gasterosteus aculeatus (1) | Gorilla gorilla (1) |
| Homo sapiens (1) | Ictidomys tridecemlineatus (1) | Latimeria chalumnae (1) |
| Macaca mulatta (1) | Macropus eugenii (1) | Meleagris gallopavo (1) |
| Mus musculus (1) | Myotis lucifugus (1) | Oreochromis niloticus (1) |
| Oryctolagus cuniculus (1) | Oryza brachyantha (1) | Oryzias latipes (1) |
| Pan troglodytes (1) | Procavia capensis (1) | Pteropus vampyrus (1) |
| Rattus norvegicus (1) | Setaria italica (1) | Takifugu rubripes (1) |
| Tetraodon nigroviridis (1) | Tursiops truncatus (1) | Xiphophorus maculatus (1) |