Kinase Classification: Asp-Based PTP MDP1※ MDP1 family introduction Magnesium-dependent phosphatase 1 (MDP1) belong to Asp-Based protein phosphatase family, which use a Asp residue as a nucleophile for catalysis. The conserved motif DXDX[TV] is also found in MDP1. Like EYA, FCP family, MDP1 also belong to the haloacid dehalogenase (HAD) superfamily. However, the domain proximal to the active site in HAD family is absent in MDP1, and makes a open state in active site which might be responsible for interactions with large substrates such as proteins (1).
Reference
1. Selengut, J.D. (2001) MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. Biochemistry, 40, 12704-12711. PMID: 11601995
Asp-Based PTP MDP1 in eukaryotes:
1. Selengut, J.D. (2001) MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. Biochemistry, 40, 12704-12711. PMID: 11601995
Asp-Based PTP MDP1 in eukaryotes:
| Bos taurus (1) | Callithrix jacchus (1) | Cavia porcellus (1) |
| Choloepus hoffmanni (1) | Ciona intestinalis (1) | Danio rerio (1) |
| Dipodomys ordii (1) | Equus caballus (1) | Gadus morhua (1) |
| Gorilla gorilla (1) | Homo sapiens (1) | Ictidomys tridecemlineatus (1) |
| Latimeria chalumnae (1) | Loxodonta africana (1) | Macaca mulatta (1) |
| Monodelphis domestica (1) | Mus musculus (1) | Mustela putorius furo (1) |
| Myotis lucifugus (1) | Nomascus leucogenys (1) | Oryctolagus cuniculus (1) |
| Otolemur garnettii (1) | Pan troglodytes (1) | Procavia capensis (1) |
| Pteropus vampyrus (1) | Rattus norvegicus (1) | Saccharomyces cerevisiae (1) |
| Sarcophilus harrisii (1) | Schizosaccharomyces pombe (1) | Sus scrofa (1) |
| Tursiops truncatus (1) |