Kinase Classification: DSP PTEN※ PTEN family introduction PTEN (phosphatase and tensin homolog deleted on chromosome ten) phosphatase is a conserved family of DUSP phosphatase, which could dephosphorylate tyrosine-, serine- and threonine-phosphorylated proteins. PTEN also act as lipid phosphatase, which dephosphorylate D3-phosphorylated inositol phospholopids (1). PTEN negatively regulates PI3 kinase-Akt signaling pathway by converting second messenger phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2). This pathway plays an important role in controlling cell proliferation, growth and survival (2). In addition to its dominant inhibitory activity in the PI3 kinase-Akt pathway, PTEN also possess potential protein phosphatase activity for its sequence similarity with PTP domain and this remains more understood.
Reference
1. Patterson, K.I., Brummer, T., O'Brien, P.M. and Daly, R.J. (2009) Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J, 418, 475-489. PMID: 19228121
2. Wang, X. and Jiang, X. (2008) PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res, 18, 807-816. PMID: 18626510
DSP PTEN in eukaryotes:
1. Patterson, K.I., Brummer, T., O'Brien, P.M. and Daly, R.J. (2009) Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J, 418, 475-489. PMID: 19228121
2. Wang, X. and Jiang, X. (2008) PTEN: a default gate-keeping tumor suppressor with a versatile tail. Cell Res, 18, 807-816. PMID: 18626510
DSP PTEN in eukaryotes: