Kinase Classification: PPP PP7※ PP7 family introduction PP7, also known as PPEF phosphatase, is ser/thr phosphatases of the PPP family. The catalytic domain of PP7 is flanked by N- and C-terminal domains. PP7 phosphatase are charactered by its EF-hand domains which is invloved in calcium-binding. This character suggests that PP7 can be regulated by Ca2+. In mammals, PP7 are found in various sensory neurons and might be invloved in sensory signalling. PP7 also act as a regulator in cell growth, cell apoptosis, proliferation or oncogenic transformation (1).
Reference
1. Andreeva, A.V. and Kutuzov, M.A. (2009) PPEF/PP7 protein Ser/Thr phosphatases. Cell Mol Life Sci, 66, 3103-3110. PMID: 19662497
PPP PP7 in eukaryotes:
1. Andreeva, A.V. and Kutuzov, M.A. (2009) PPEF/PP7 protein Ser/Thr phosphatases. Cell Mol Life Sci, 66, 3103-3110. PMID: 19662497
PPP PP7 in eukaryotes: