※ PPP_Unique family introduction

    Phosphoprotein phosphatase (PPP) family is highly conserved among all eukaryotes. Seven phosphatases compose of PPP family in human genome, which are known as PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6 and PP7. PPP family phosphatase share a conserved catalytic domain ~280 amino acid and three signature motifs (-GDXHG-, -GDXVDRG- and -GNHE-) in this domain. The catalytic subunit of several members in PPP family always associates with a number of regulatory subunits, which regular the substrate recognition and function. For PPP family members, metal ions play a important role during dephosphorylation reaction (1).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837