Kinase Classification: PTP-Other SSU72※ SSU72 family introduction SSU72 was originally identified as a transcription/RNA processing factor interacting with the TFIIB transcription factor in yeast. Further studies show that SSU72 can also mediate the regulation of cell viability and it is conserved among eukaryotic organisms. SSU72 possesses the phosphatase activity and the conserved catalytic motif CX5R of PTP also present in SSU72. SSU72 is thought to be Asp-based PTP and the mutation of aspartate will lead to the decreased phosphatase activity. One identified substrate is C-terminal domain of RNA polymerase II (1).
Reference
1. Kim, H.S., Baek, K.H., Ha, G.H., Lee, J.C., Kim, Y.N., Lee, J., Park, H.Y., Lee, N.R., Lee, H., Cho, Y. et al. (2010) The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO J, 29, 3544-3557. PMID: 20818333
PTP-Other SSU72 in eukaryotes:
1. Kim, H.S., Baek, K.H., Ha, G.H., Lee, J.C., Kim, Y.N., Lee, J., Park, H.Y., Lee, N.R., Lee, H., Cho, Y. et al. (2010) The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO J, 29, 3544-3557. PMID: 20818333
PTP-Other SSU72 in eukaryotes: