Kinase Classification: PTP-Other TULA-1※ TULA-1 family introduction TULA/STS contain two members, UBASH3A/TULA-1 and UBASH3B/TULA-2. Sequence analysis show that they share a conserved multidomain structure, they contain an N-terminal ubiquitin-association domain, followed by a Src-homology 3 domain, and a C-terminal phosphatase domain. TULA/STS show tyrosine phosphatase activity toward para-nitrophenyl phosphate, phosphotyrosine peptides and phosphoprotein ZAP70, Syk and certain Src family members. TULA/STS are distinct from other PTP which use a cysteine residue as a catalytic residue, TULA/STS utilize a "D" to catalyze the dephosphorylation. TULA/STS show some sequence similarity with histidine phosphatase superfamily (1).
Reference
1. Chen, X., Ren, L., Kim, S., Carpino, N., Daniel, J.L., Kunapuli, S.P., Tsygankov, A.Y. and Pei, D. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem, 285, 31268-31276. PMID: 20670933
PTP-Other TULA-1 in eukaryotes:
1. Chen, X., Ren, L., Kim, S., Carpino, N., Daniel, J.L., Kunapuli, S.P., Tsygankov, A.Y. and Pei, D. (2010) Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. J Biol Chem, 285, 31268-31276. PMID: 20670933
PTP-Other TULA-1 in eukaryotes:
| Ailuropoda melanoleuca (1) | Anolis carolinensis (1) | Bos taurus (1) |
| Callithrix jacchus (1) | Canis familiaris (1) | Cavia porcellus (1) |
| Equus caballus (1) | Felis catus (1) | Gallus gallus (1) |
| Gorilla gorilla (1) | Homo sapiens (1) | Ictidomys tridecemlineatus (1) |
| Latimeria chalumnae (1) | Loxodonta africana (1) | Macaca mulatta (1) |
| Meleagris gallopavo (1) | Monodelphis domestica (1) | Mus musculus (1) |
| Mustela putorius furo (1) | Myotis lucifugus (1) | Nomascus leucogenys (1) |
| Ornithorhynchus anatinus (1) | Oryctolagus cuniculus (1) | Otolemur garnettii (1) |
| Pan troglodytes (1) | Pongo abelii (1) | Rattus norvegicus (1) |
| Sarcophilus harrisii (1) | Sus scrofa (1) | Taeniopygia guttata (1) |