※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00212	ENSGACG00000002801	PRKCE (2 of 2)
2		EKS-GAA-00208	ENSGACG00000018519	PRKCA (2 of 2)
3		EKS-GAA-00204	ENSGACG00000014351	PRKCB (2 of 2)
4		EKS-GAA-00205	ENSGACG00000011409	PRKCE (1 of 2)
5		EKS-GAA-00206	ENSGACG00000010646	PRKCG
6		EKS-GAA-00211	ENSGACG00000020094	PRKCQ
7		EKS-GAA-00202	ENSGACG00000016775	PRKCB (1 of 2)
8		EKS-GAA-00209	ENSGACG00000008506	PRKCH
9		EKS-GAA-00207	ENSGACG00000016956	PRKCI
10		EKS-GAA-00213	ENSGACG00000000771	PRKCD (2 of 2); PRKCD (1 of 2)
11		EKS-GAA-00203	ENSGACG00000011652	PRKCA (1 of 2)
12		EKS-GAA-00210	ENSGACG00000013018	PRKCZ
13		EKS-GAA-00214	ENSGACG00000009511	PRKCD (2 of 2); PRKCD (1 of 2)