※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00176	ENSMODG00000022776
2		EKS-MOD-00172	ENSMODG00000010650	PRKCD
3		EKS-MOD-00175	ENSMODG00000024997
4		EKS-MOD-00174	ENSMODG00000024996
5		EKS-MOD-00171	ENSMODG00000020916	LOC100030202
6		EKS-MOD-00170	ENSMODG00000016076	PRKCI
7		EKS-MOD-00169	ENSMODG00000008706	PRKCH
8		EKS-MOD-00167	ENSMODG00000016311	PRKCB
9		EKS-MOD-00173	ENSMODG00000016663	PRKCQ
10		EKS-MOD-00168	ENSMODG00000004147	PRKCA