※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00300	ENSMODG00000005729	ALPK1
2		EKS-MOD-00297	ENSMODG00000002196	TRPM7
3		EKS-MOD-00298	ENSMODG00000002031	TRPM6
4		EKS-MOD-00302	ENSMODG00000019366	ALPK3
5		EKS-MOD-00299	ENSMODG00000007732	EEF2K
6		EKS-MOD-00301	ENSMODG00000020435	ALPK2