※ Alpha family introduction

    Alpha kinases belong to atypical kinase group and lack significant sequence similarity to ePK (1). Six members have been identified in mammals, including elongation factor 2 kinase, Dictyostelium myosin heavy chain kinases and other protein kinases. eEF-2 is involve in regulation of the global rate of protein synthesis and MHCK A is essential in regualtion of myosin assembly and disassembly. Although no detectable sequence identity between ePK and Alpha kinases has been found, the structure, sequence motifs and key amino acid residue position are very similar. The differences may impact on substrate recognition (2).

Reference
1. Manning, G., Whyte, D.B., Martinez, R., Hunter, T. and Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912-1934. PMID: 12471243
2. Drennan, D. and Ryazanov, A.G. (2004) Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol, 85, 1-32. PMID: 15050379

  Reviewed (0)  or Unreviewed (5) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00400	ENSTRUG00000012167	ALPK2
2		EKS-TAR-00399	ENSTRUG00000012128	ALPK1
3		EKS-TAR-00397	ENSTRUG00000006251	TRPM7
4		EKS-TAR-00398	ENSTRUG00000001357	TRPM6
5		EKS-TAR-00401	ENSTRUG00000004542	ALPK3