Bos taurus      Atypical      RIO

※ RIO family introduction

    RIO family belongs to atypical protein kinase group, which share little similarity of high kinase domain with ePK. RIO family is present in organisms varying from archaea to humans. All these organisms contain at least two RIO proteins, Rio1 and Rio2, but a third Rio3 group is present in multicellular eukaryotes. Rio1 and Rio2 possess kinase activity which has been demonstrated shown to be essential in S. cerevisiae and required for proper cell cycle progression and chromosome maintenance (1).

Reference
1. LaRonde-LeBlanc, N. and Wlodawer, A. (2005) The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. Biochim Biophys Acta, 1754, 14-24. PMID: 16182620


There are 3 genes.  Reviewed (1 or Unreviewed (2

No.StatusEKPD IDGene IDGene Name
1
EKS-BOT-00144
ENSBTAG00000011763
BT.19348; RIOK2
2
EKS-BOT-00143
ENSBTAG00000010042
RIOK3
3
EKS-BOT-00142
ENSBTAG00000013821
BT.89457; RIOK1