※ CAMK1 family introduction

    CAMK1 family consists of six family members in human. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Family member CAMK1 is a monomeric 42KD enzyme distributed in most mammalian cell types. CAMK1 contains a protein kinase catalytic domain flanked by an ATP bind lobe and protein substrates bind lobe. CAMK1 keeps an inhibited state normally, with the ATP binding lobe interacting with AID domain. Active CAMK1 prefer the substrate containing a basic residue at the P-3 position and a hydrophobic residue at P-5 (1). CAMK1 act as a key molecule in calcium-triggered CaMKK-CaMK1 signaling cascade, and regulates a variety of cellular processes including transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, neurite outgrowth and also involve in regulation of axonal extension and growth cone motility in hippocampal and cerebellar nerve cells (2).

Reference
1. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376
2. Kamata, A., Sakagami, H., Tokumitsu, H., Owada, Y., Fukunaga, K. and Kondo, H. (2007) Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res, 57, 86-97. PMID: 17056143

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00585	ENSGACG00000019160	CAMK1D (1 of 2)
2		EKS-GAA-00588	ENSGACG00000011358	CAMK1G (1 of 2)
3		EKS-GAA-00591	ENSGACG00000010570	CAMKV (2 of 2)
4		EKS-GAA-00586	ENSGACG00000004485	CAMK1D (2 of 2)
5		EKS-GAA-00587	ENSGACG00000011590	CAMK1G (2 of 2)
6		EKS-GAA-00584	ENSGACG00000000319	CAMK1 (2 of 2)
7		EKS-GAA-00590	ENSGACG00000011998	CAMKV (1 of 2)
8		EKS-GAA-00589	ENSGACG00000013599	CAMK4
9		EKS-GAA-00592	ENSGACG00000009900
10		EKS-GAA-00583	ENSGACG00000001365	CAMK1 (1 of 2)