※ CAMK1 family introduction

    CAMK1 family consists of six family members in human. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Family member CAMK1 is a monomeric 42KD enzyme distributed in most mammalian cell types. CAMK1 contains a protein kinase catalytic domain flanked by an ATP bind lobe and protein substrates bind lobe. CAMK1 keeps an inhibited state normally, with the ATP binding lobe interacting with AID domain. Active CAMK1 prefer the substrate containing a basic residue at the P-3 position and a hydrophobic residue at P-5 (1). CAMK1 act as a key molecule in calcium-triggered CaMKK-CaMK1 signaling cascade, and regulates a variety of cellular processes including transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, neurite outgrowth and also involve in regulation of axonal extension and growth cone motility in hippocampal and cerebellar nerve cells (2).

Reference
1. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376
2. Kamata, A., Sakagami, H., Tokumitsu, H., Owada, Y., Fukunaga, K. and Kondo, H. (2007) Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res, 57, 86-97. PMID: 17056143

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00487	ENSLAFG00000016446	CAMK1
2		EKS-LOA-00491	ENSLAFG00000022618	CAMKV
3		EKS-LOA-00488	ENSLAFG00000005219	CAMK1G
4		EKS-LOA-00486	ENSLAFG00000000154	CAMK1D
5		EKS-LOA-00490	ENSLAFG00000006634	CAMK4
6		EKS-LOA-00489	ENSLAFG00000013695	PNCK