※ CAMK1 family introduction

    CAMK1 family consists of six family members in human. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Family member CAMK1 is a monomeric 42KD enzyme distributed in most mammalian cell types. CAMK1 contains a protein kinase catalytic domain flanked by an ATP bind lobe and protein substrates bind lobe. CAMK1 keeps an inhibited state normally, with the ATP binding lobe interacting with AID domain. Active CAMK1 prefer the substrate containing a basic residue at the P-3 position and a hydrophobic residue at P-5 (1). CAMK1 act as a key molecule in calcium-triggered CaMKK-CaMK1 signaling cascade, and regulates a variety of cellular processes including transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, neurite outgrowth and also involve in regulation of axonal extension and growth cone motility in hippocampal and cerebellar nerve cells (2).

Reference
1. Soderling, T.R. and Stull, J.T. (2001) Structure and regulation of calcium/calmodulin-dependent protein kinases. Chem Rev, 101, 2341-2352. PMID: 11749376
2. Kamata, A., Sakagami, H., Tokumitsu, H., Owada, Y., Fukunaga, K. and Kondo, H. (2007) Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res, 57, 86-97. PMID: 17056143

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORL-00560	ENSORLG00000013945	CAMK4
2		EKS-ORL-00557	ENSORLG00000020798	CAMK1D (1 of 2)
3		EKS-ORL-00555	ENSORLG00000016042	CAMK1
4		EKS-ORL-00558	ENSORLG00000016226	CAMK1G (1 of 2)
5		EKS-ORL-00563	ENSORLG00000008530
6		EKS-ORL-00556	ENSORLG00000003942	CAMK1D (2 of 2)
7		EKS-ORL-00562	ENSORLG00000003516	CAMKV (2 of 2)
8		EKS-ORL-00561	ENSORLG00000014299	CAMKV (1 of 2)
9		EKS-ORL-00559	ENSORLG00000010272	CAMK1G (2 of 2)