※ DAPK family introduction

    DAPK (Death-associated protein kinase) belong to the CAMK family. DAPK contains DAPK1, DAPK, Zipper interacting kinase (ZIPK, also named DAPK-3), DAP kinase related apoptosis inducing protein kinase DRAK1 and DRAK2. They share a highly conserved catalytic domain and diverse extracatalytic domainsm which associated with different functions. DAPK proteins are activated downstream of a variety of cell signaling pathway. And then induce cell death via p53 or p53-independent induced apoptosis, and also via autophagy and membrane blebbing induced cell death. In addition, death signal can also stimuli the DAPK cascade signaling pathway and finally induce cell death (1).

Reference
1. Lin, Y., Hupp, T.R. and Stevens, C. (2010) Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. FEBS J, 277, 48-57. PMID: 19878313

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00507	ENSGACG00000014591	DAPK1
2		EKS-GAA-00505	ENSGACG00000010201	DAPK2 (2 of 2)
3		EKS-GAA-00508	ENSGACG00000008544
4		EKS-GAA-00504	ENSGACG00000016942	DAPK3
5		EKS-GAA-00509	ENSGACG00000000903	STK17A
6		EKS-GAA-00506	ENSGACG00000017307	DAPK2 (1 of 2)
7		EKS-GAA-00511	ENSGACG00000001301
8		EKS-GAA-00510	ENSGACG00000001676	STK17B