※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-FEC-00251	ENSFCAG00000011099	DYRK2
2		EKS-FEC-00257	ENSFCAG00000003021	DYRK1B
3		EKS-FEC-00259	ENSFCAG00000030050	PRPF4B
4		EKS-FEC-00256	ENSFCAG00000023639	HIPK3
5		EKS-FEC-00252	ENSFCAG00000025106	DYRK3
6		EKS-FEC-00255	ENSFCAG00000024560	DYRK1A
7		EKS-FEC-00260	ENSFCAG00000001029	HIPK4
8		EKS-FEC-00254	ENSFCAG00000009242	HIPK1
9		EKS-FEC-00253	ENSFCAG00000010565	HIPK2
10		EKS-FEC-00258	ENSFCAG00000022967	DYRK4