※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-DAR-00330	ENSDARG00000052468	GSK3B (2 of 2); si:dkeyp-80c12.7
2		EKS-DAR-00331	ENSDARG00000015681	GSK3, gsk3a; gsk3ab
3		EKS-DAR-00329	ENSDARG00000017803	GSK3; gsk3b
4		EKS-DAR-00332	ENSDARG00000029501	CH211-39E15.2, si:ch211-39e15.2; CH211-39E15.2-001; gsk3aa