※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (5)  or Unreviewed (3) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-ART-00005	AT2G35680	T20F21.13; At2g35680; AT2G35680; DSP8
2		EPS-ART-00010	AT3G10940	LSF2; F9F8.24; AT3G10940; At3g10940
3		EPS-ART-00006	AT5G56610	AT5G56610; At5g56610
4		EPS-ART-00009	AT3G52180	PTPKIS1, SEX4; F4F15.290; SEX4; DSP4; At3g52180
5		EPS-ART-00007	AT3G01510	F4P13.6; LSF1; PTPKIS2; At3g01510
6		EPS-ART-00011	AT5G01290	At5g01290; AT5G01290
7		EPS-ART-00004	AT5G23720	MQM1.1; PHS1; At5g23720
8		EPS-ART-00008	AT3G09100	At3g09100; AT3G09100