※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-ICT-00007	ENSSTOG00000005514	DUSP13
2		EPS-ICT-00011	ENSSTOG00000001730	DUSP22
3		EPS-ICT-00013	ENSSTOG00000025153	DUSP12
4		EPS-ICT-00002	ENSSTOG00000029009	DUPD1
5		EPS-ICT-00014	ENSSTOG00000026128	DUSP28
6		EPS-ICT-00010	ENSSTOG00000002528	DUSP14
7		EPS-ICT-00016	ENSSTOG00000022917	DUSP11
8		EPS-ICT-00003	ENSSTOG00000025959	DUSP26
9		EPS-ICT-00009	ENSSTOG00000010472	DUSP27
10		EPS-ICT-00018	ENSSTOG00000002289	DUSP23
11		EPS-ICT-00015	ENSSTOG00000025670	EPM2A
12		EPS-ICT-00017	ENSSTOG00000019770	PTPMT1
13		EPS-ICT-00006	ENSSTOG00000020279
14		EPS-ICT-00012	ENSSTOG00000026975	DUSP15
15		EPS-ICT-00008	ENSSTOG00000013789	DUSP3
16		EPS-ICT-00005	ENSSTOG00000007072	DUSP21
17		EPS-ICT-00019	ENSSTOG00000007145	RNGTT
18		EPS-ICT-00004	ENSSTOG00000023137