※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SUS-00010	ENSSSCG00000029874	DUSP14
2		EPS-SUS-00003	ENSSSCG00000015835	DUSP26
3		EPS-SUS-00006	ENSSSCG00000010318	DUSP13
4		EPS-SUS-00002	ENSSSCG00000010317	DUPD1
5		EPS-SUS-00012	ENSSSCG00000006347	DUSP12; LOC100626531
6		EPS-SUS-00009	ENSSSCG00000006311	LOC100737362
7		EPS-SUS-00013	ENSSSCG00000013226	PTPMT1
8		EPS-SUS-00005	ENSSSCG00000010013	DUSP18; LOC100156909
9		EPS-SUS-00004	ENSSSCG00000029128	LOC100152994
10		EPS-SUS-00015	ENSSSCG00000028090	DUSP23
11		EPS-SUS-00008	ENSSSCG00000020744	DUSP3
12		EPS-SUS-00011	ENSSSCG00000016161
13		EPS-SUS-00014	ENSSSCG00000004122	EPM2A
14		EPS-SUS-00007	ENSSSCG00000023500	DUSP21; Ssc.95178