※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-TAG-00020	ENSTGUG00000016440	DUSP23
2		EPS-TAG-00015	ENSTGUG00000004124
3		EPS-TAG-00019	ENSTGUG00000004122	DUSP11
4		EPS-TAG-00012	ENSTGUG00000002946	DUSP3
5		EPS-TAG-00018	ENSTGUG00000010784	EPM2A
6		EPS-TAG-00021	ENSTGUG00000012427	RNGTT
7		EPS-TAG-00016	ENSTGUG00000005500	DUSP28
8		EPS-TAG-00007	ENSTGUG00000006625	DUPD1
9		EPS-TAG-00008	ENSTGUG00000006610	DUSP13
10		EPS-TAG-00009	ENSTGUG00000006608
11		EPS-TAG-00014	ENSTGUG00000006604	DUSP15
12		EPS-TAG-00013	ENSTGUG00000002152	DUSP22
13		EPS-TAG-00010	ENSTGUG00000017306	DUSP26
14		EPS-TAG-00011	ENSTGUG00000013509	DUSP27
15		EPS-TAG-00017	ENSTGUG00000010369	PTPMT1