※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-TAR-00030	ENSTRUG00000018322	EPM2A
2		EPS-TAR-00025	ENSTRUG00000003462	DUSP22
3		EPS-TAR-00032	ENSTRUG00000007213	DUSP23
4		EPS-TAR-00027	ENSTRUG00000004472	VCPIP1
5		EPS-TAR-00023	ENSTRUG00000011751	DUSP27
6		EPS-TAR-00020	ENSTRUG00000005865	DUSP3 (2 of 2)
7		EPS-TAR-00010	ENSTRUG00000018624	DUSP26; DUSP26 (1 of 2)
8		EPS-TAR-00021	ENSTRUG00000004878	DUSP14
9		EPS-TAR-00026	ENSTRUG00000005115
10		EPS-TAR-00024	ENSTRUG00000001098	DUSP21
11		EPS-TAR-00019	ENSTRUG00000002564	DUSP26 (2 of 2)
12		EPS-TAR-00033	ENSTRUG00000017802	RNGTT
13		EPS-TAR-00014	ENSTRUG00000014750
14		EPS-TAR-00017	ENSTRUG00000014747
15		EPS-TAR-00016	ENSTRUG00000014736	DUSP13
16		EPS-TAR-00011	ENSTRUG00000014727	DUPD1 (2 of 2); DUPD1
17		EPS-TAR-00012	ENSTRUG00000013599
18		EPS-TAR-00029	ENSTRUG00000014669	NDUFS3
19		EPS-TAR-00013	ENSTRUG00000013585	DUPD1 (1 of 2)
20		EPS-TAR-00015	ENSTRUG00000013616
21		EPS-TAR-00022	ENSTRUG00000011568	IRF4 (2 of 2)
22		EPS-TAR-00028	ENSTRUG00000004164	DUSP12
23		EPS-TAR-00031	ENSTRUG00000008689	PTPDC1
24		EPS-TAR-00018	ENSTRUG00000005425	DUSP3 (1 of 2)