※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAG-00299	ENSGALG00000010314	NEK9
2		EKS-GAG-00294	ENSGALG00000001118	RCJMB04_14d10; NEK6
3		EKS-GAG-00293	ENSGALG00000001672	NEK4
4		EKS-GAG-00301	ENSGALG00000002216	NEK7
5		EKS-GAG-00292	ENSGALG00000009683	NEK1
6		EKS-GAG-00295	ENSGALG00000017024	NEK3
7		EKS-GAG-00298	ENSGALG00000017023	NEK5
8		EKS-GAG-00296	ENSGALG00000009854	NEK2
9		EKS-GAG-00300	ENSGALG00000011598	NEK11
10		EKS-GAG-00302	ENSGALG00000011322	NEK10
11		EKS-GAG-00297	ENSGALG00000003979	NEK8