※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM), includes protein phosphatases which dependent on manganese/magnesium ions (Mn2+/Mg2+). PPM family contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determine the substrate recognition and function diversity. Like PPP family, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is the largest protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor proteins (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-CII-00012	ENSCING00000007208	CIN.51027; LOC100183669
2		EPS-CII-00011	ENSCING00000002414	CIN.29243; LOC100181128
3		EPS-CII-00013	ENSCING00000024121	LOC100185994; CIN.1956
4		EPS-CII-00015	ENSCING00000003713	LOC100179989
5		EPS-CII-00002	ENSCING00000007973	CIN.38000; LOC100181266
6		EPS-CII-00010	ENSCING00000004389	CIN.23441; LOC100178049
7		EPS-CII-00009	ENSCING00000008148	LOC100183363; CIN.20702
8		EPS-CII-00014	ENSCING00000012896