Schizosaccharomyces pombe      STE      STE11

※ STE11 family introduction

    STE11 family kinases are mitogen-activated protein kinase kinase kinase. Eight kinases compose this family and act as an essential component of the MAP kinase signal transduction pathway. STE11 family contains some subfamilys. MAP3K1/2/3/5/6 appears to diverged from SC:STE11, SCBCK1, SP:MHK1 and SP:BR2. SC:STE11 plays an important role in mating and filamentation-invasion pathways, BCK1 is responsible for nutrient sensing and growth, MHK1 is involved in cell-wall integrity, BYR2 participate innutrient sensing and pheromone signaling. MAP3K1/2/3/5/6 also act as key molecules in the JNK pathway, inflammation and cell apoptosis (1).

Reference
1. Kinase Pathway Database:STE11 Family


There are 5 genes.  Reviewed (5 or Unreviewed (0

No.StatusEKPD IDGene IDGene Name
1
EKS-SCP-00002
SPAC9G1.02
wak1, wik1; SPAC9G1.02; wis4
2
EKS-SCP-00005
SPAC1006.09
SPAC1006.09, SPAC1250.06c, SPAPJ730.01; win1
3
EKS-SCP-00003
SPBC1D7.05
byr2; ste8; SPBC1D7.05, SPBC2F12.01
4
EKS-SCP-00001
SPAC1F3.02c
mkh1; SPAC1F3.02c
5
EKS-SCP-00004
SPBC21.06c
SPBC21.06c; cdc7