※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (21) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00008	ENSTRUG00000007447	EPHA4 (2 of 2)
2		EKS-TAR-00004	ENSTRUG00000007094	EPHB3 (1 of 2)
3		EKS-TAR-00013	ENSTRUG00000007205	EPHB3 (2 of 2)
4		EKS-TAR-00007	ENSTRUG00000013083	EPHB1 (1 of 2)
5		EKS-TAR-00016	ENSTRUG00000011705	EPHA2 (2 of 2)
6		EKS-TAR-00012	ENSTRUG00000018413	EPHB1 (2 of 2)
7		EKS-TAR-00015	ENSTRUG00000002757
8		EKS-TAR-00019	ENSTRUG00000006367	EPHA10
9		EKS-TAR-00011	ENSTRUG00000006416
10		EKS-TAR-00018	ENSTRUG00000006475	EPHA7
11		EKS-TAR-00002	ENSTRUG00000001793	EPHA3
12		EKS-TAR-00006	ENSTRUG00000005841	EPHB2 (1 of 2)
13		EKS-TAR-00014	ENSTRUG00000001093	EPHA2 (1 of 2)
14		EKS-TAR-00005	ENSTRUG00000015696	EPHA5
15		EKS-TAR-00010	ENSTRUG00000005498	EPHB2 (2 of 2)
16		EKS-TAR-00021	ENSTRUG00000000025	EPHA8
17		EKS-TAR-00009	ENSTRUG00000016825	EPHB4
18		EKS-TAR-00003	ENSTRUG00000003966	EPHA6 (1 of 2)
19		EKS-TAR-00020	ENSTRUG00000008107	EPHB6
20		EKS-TAR-00017	ENSTRUG00000017240	EPHA6 (2 of 2)
21		EKS-TAR-00001	ENSTRUG00000008442	EPHA4 (1 of 2)