※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (22) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00001	ENSTNIG00000016418	EPHA3
2		EKS-TEN-00022	ENSTNIG00000012202	GSTENG00022950001; EPHB2 (1 of 2)
3		EKS-TEN-00013	ENSTNIG00000004615
4		EKS-TEN-00007	ENSTNIG00000004614	EPHB4 (3 of 3)
5		EKS-TEN-00010	ENSTNIG00000004829	EPHA5
6		EKS-TEN-00019	ENSTNIG00000017736	EPHA10
7		EKS-TEN-00005	ENSTNIG00000006519	EPHB2 (2 of 2); EPHB2
8		EKS-TEN-00004	ENSTNIG00000006035
9		EKS-TEN-00017	ENSTNIG00000009429	EPHA6 (2 of 2)
10		EKS-TEN-00008	ENSTNIG00000018078	EPHB1 (3 of 3); EPHB1 (2 of 2)
11		EKS-TEN-00002	ENSTNIG00000014314	EPHA4 (1 of 2)
12		EKS-TEN-00011	ENSTNIG00000010040	EPHB4 (2 of 3); EPHB4
13		EKS-TEN-00015	ENSTNIG00000010041	EPHB4 (1 of 3)
14		EKS-TEN-00016	ENSTNIG00000014755	EPHA2 (2 of 2)
15		EKS-TEN-00014	ENSTNIG00000010906	EPHA2 (1 of 2)
16		EKS-TEN-00020	ENSTNIG00000008297	EPHB6
17		EKS-TEN-00006	ENSTNIG00000015345	EPHA4 (2 of 2)
18		EKS-TEN-00003	ENSTNIG00000015277	EPHB1 (2 of 3)
19		EKS-TEN-00012	ENSTNIG00000007814	EPHB3
20		EKS-TEN-00021	ENSTNIG00000003594
21		EKS-TEN-00018	ENSTNIG00000007251	EPHA7
22		EKS-TEN-00009	ENSTNIG00000007383	EPHA8