※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00382	ENSLAFG00000016890	PTK6
2		EKS-LOA-00383	ENSLAFG00000011490	LCK
3		EKS-LOA-00379	ENSLAFG00000011018	FGR
4		EKS-LOA-00378	ENSLAFG00000011161	HCK
5		EKS-LOA-00377	ENSLAFG00000007811	LYN
6		EKS-LOA-00380	ENSLAFG00000005589	FRK
7		EKS-LOA-00381	ENSLAFG00000006812	BLK
8		EKS-LOA-00376	ENSLAFG00000002384	YES1
9		EKS-LOA-00375	ENSLAFG00000014637	SRC
10		EKS-LOA-00374	ENSLAFG00000002604	FYN