※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (1)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAP-00415	ENSCPOG00000012519	ILK_CAVPO; ILK
2		EKS-CAP-00411	ENSCPOG00000001803	MAP3K9
3		EKS-CAP-00409	ENSCPOG00000014215	MAP3K11
4		EKS-CAP-00412	ENSCPOG00000014720	MAP3K13
5		EKS-CAP-00410	ENSCPOG00000015417	MAP3K10
6		EKS-CAP-00414	ENSCPOG00000008242	MAP3K7
7		EKS-CAP-00413	ENSCPOG00000000971	MAP3K12