※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00069	ENSGACG00000014173	KSR2
2		EKS-GAA-00067	ENSGACG00000019257	BRAF
3		EKS-GAA-00070	ENSGACG00000003668	ARAF
4		EKS-GAA-00071	ENSGACG00000020303	KSR1 (1 of 2)
5		EKS-GAA-00068	ENSGACG00000000060	RAF1
6		EKS-GAA-00072	ENSGACG00000013663	KSR1 (2 of 2)