※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547

  Reviewed (0)  or Unreviewed (5) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORN-00071	ENSONIG00000010417	ARAF
2		EKS-ORN-00072	ENSONIG00000010586	KSR2
3		EKS-ORN-00074	ENSONIG00000014814	KSR1 (2 of 2)
4		EKS-ORN-00073	ENSONIG00000001966	KSR1 (1 of 2)
5		EKS-ORN-00070	ENSONIG00000017170	RAF1