Pongo abelii      TKL      RAF

※ RAF family introduction

    RAF kinases are serine/threonine kinase and belong to TKL family. Sequence analysis of RAF kinase shows that three conserved domain is present in RAFs, known as CR1-3. CR1 contains two Ras binding domains (RBD and CRD), serine/threonine are rich in CR2 and CR3 contains a protein kinase catalytic domain. RAFs are key regulator involved in RAS-RAF-MEK-ERK signal transduction cascade, also known as MAPK cascade. RAS is activated by GTPase via a multistage process. Activate RAFs will subsequently lead to the activation of MEK1 and MEK2 and transduce the signal to downstream molecules (1).

Reference
1. Roskoski, R., Jr. (2010) RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun, 399, 313-317. PMID: 20674547


There are 5 genes.  Reviewed (1 or Unreviewed (4

No.StatusEKPD IDGene IDGene Name
1
EKS-POA-00047
ENSPPYG00000018061
BRAF
2
EKS-POA-00049
ENSPPYG00000020295
ARAF
3
EKS-POA-00051
ENSPPYG00000008077
KSR1
4
EKS-POA-00050
ENSPPYG00000005006
KSR2
5
EKS-POA-00048
ENSPPYG00000013388
RAF1