※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-FEC-00263	ENSFCAG00000011271	ACVR1C
2		EKS-FEC-00269	ENSFCAG00000003157	ACVR2B
3		EKS-FEC-00268	ENSFCAG00000023845	ACVR2A
4		EKS-FEC-00264	ENSFCAG00000008054	ACVR1
5		EKS-FEC-00272	ENSFCAG00000005894	AMHR2
6		EKS-FEC-00262	ENSFCAG00000026263	ACVR1B
7		EKS-FEC-00271	ENSFCAG00000014094	BMPR2
8		EKS-FEC-00267	ENSFCAG00000000265	ACVRL1
9		EKS-FEC-00270	ENSFCAG00000004384	TGFBR2
10		EKS-FEC-00261	ENSFCAG00000027261	TGFBR1
11		EKS-FEC-00265	ENSFCAG00000022227	BMPR1B
12		EKS-FEC-00266	ENSFCAG00000027895	BMPR1A