※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MUP-00278	ENSMPUG00000002620	Acvr2b
2		EKS-MUP-00275	ENSMPUG00000008847	Bmpr1a
3		EKS-MUP-00274	ENSMPUG00000002097	Bmpr1b
4		EKS-MUP-00277	ENSMPUG00000003611	ACVR2A
5		EKS-MUP-00280	ENSMPUG00000007757	ACVR1B
6		EKS-MUP-00276	ENSMPUG00000007859	Acvrl1
7		EKS-MUP-00279	ENSMPUG00000011952	TGFBR2
8		EKS-MUP-00272	ENSMPUG00000000465	Acvr1
9		EKS-MUP-00273	ENSMPUG00000000461	ACVR1C
10		EKS-MUP-00281	ENSMPUG00000000354	Bmpr2
11		EKS-MUP-00271	ENSMPUG00000006676	TGFBR1
12		EKS-MUP-00282	ENSMPUG00000006005	Amhr2