※ DMPK family introduction

    DMPK (myotonic dystrophy protein kinase) belong to AGC family, which was first described in 1909 to have relation with myotonic dystrophy. The phylogenetic tree of DMPK family shows this family also includes ROCKs (Rho kinases), MRCK (cell division control protein 42 (Cdc42)-binding kinases) and citron kinase. Sequence analysis shows that these kinases contain an amino-terminal kinase catalytic domain followed by a coiled-coil-forming region and other functional motifs at the C-terminus. DMPK have been probed by synthetic peptides or putative physiological substrates to possess Serine/Threonine kinase activity, many proteins targeted by DMPK show a consensus motif R x x S/T L/V R, which is similar to PKC. DMPK have been shown to act as a key molecule in regulation these in varieties of cellular processes, including regulation of skeletal muscle proper structure and function, ion-channel gating control and cell metabolism. In addition, abnormal expression or genetic defect of DMPK associated with myotonic dystrophy 1 (1).

Reference
1. Kaliman, P. and Llagostera, E. (2008) Myotonic dystrophy protein kinase (DMPK) and its role in the pathogenesis of myotonic dystrophy 1. Cell Signal, 20, 1935-1941. PMID: 18583094

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00538	ENSGACG00000012788	ROCK2 (1 of 2)
2		EKS-GAA-00535	ENSGACG00000004707	CDC42BPA
3		EKS-GAA-00540	ENSGACG00000008628	CIT (2 of 2)
4		EKS-GAA-00537	ENSGACG00000013698	CDC42BPB
5		EKS-GAA-00536	ENSGACG00000017327	ROCK1
6		EKS-GAA-00539	ENSGACG00000009555	ROCK2 (2 of 2)