※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORA-00153	ENSOANG00000009091	PRKCH
2		EKS-ORA-00151	ENSOANG00000000308	PRKCI
3		EKS-ORA-00150	ENSOANG00000001477	PRKCB
4		EKS-ORA-00152	ENSOANG00000015452	PRKCQ
5		EKS-ORA-00155	ENSOANG00000004136	PRKCD
6		EKS-ORA-00154	ENSOANG00000010041	PRKCZ
7		EKS-ORA-00149	ENSOANG00000008060	PRKCA