※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SUS-00146	ENSSSCG00000008444	PRKCE
2		EKS-SUS-00152	ENSSSCG00000025037	PRKCB
3		EKS-SUS-00148	ENSSSCG00000005095	PRKCH; PKC
4		EKS-SUS-00151	ENSSSCG00000017268	PRKCA
5		EKS-SUS-00149	ENSSSCG00000011745	PRKCI
6		EKS-SUS-00150	ENSSSCG00000023503	PRKCD
7		EKS-SUS-00153	ENSSSCG00000011131	PRKCQ
8		EKS-SUS-00147	ENSSSCG00000003256	PRKCG