※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (9) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAG-00201	ENSTGUG00000010959	PRKCI
2		EKS-TAG-00197	ENSTGUG00000004257	PRKCA
3		EKS-TAG-00204	ENSTGUG00000004544	PRKCD
4		EKS-TAG-00205	ENSTGUG00000015253
5		EKS-TAG-00198	ENSTGUG00000003908	PRKCE
6		EKS-TAG-00202	ENSTGUG00000002957	PRKCZ
7		EKS-TAG-00203	ENSTGUG00000002037	PRKCQ
8		EKS-TAG-00200	ENSTGUG00000006215	PRKCB
9		EKS-TAG-00199	ENSTGUG00000012981	PRKCH