※ PKC family introduction

    PKC (protein kinase C) belong to AGC family. PKC can be subgrouped into three sections based on similar structural and activation requirements: classical, novel and atypical. Classical PKCs are activated by calcium, phosphatidylserine and diacylglycerol or phorbol esters. The novel PKCs lack a conserved region found in classical PKC and activated by different lipids. The atypical PKCs is smallest in size in all PKCs, they are activated dephend on PS. PKCs keep an inactive state in the cytosol and translocate to the membrane vesicles, nuclear structures and cytoskeletal components after cell stimulation. Activated PKCs have been shown to involve in a varieties cellular processes including receptor desensitization, modulating membrane structure, regulating transcription, mediating immune responses, regulating cell growth and learning and memory (1).

Reference
1. Keenan, C. and Kelleher, D. (1998) Protein kinase C and the cytoskeleton. Cell Signal, 10, 225-232. PMID: 9617479

  Reviewed (0)  or Unreviewed (14) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TEN-00215	ENSTNIG00000005329	PRKCE (2 of 2)
2		EKS-TEN-00220	ENSTNIG00000012644	PRKCQ
3		EKS-TEN-00219	ENSTNIG00000004949	PRKCZ
4		EKS-TEN-00217	ENSTNIG00000017340	PRKCH
5		EKS-TEN-00212	ENSTNIG00000017985	PRKCA (2 of 2)
6		EKS-TEN-00214	ENSTNIG00000009867	PRKCE (1 of 2); PRKCE
7		EKS-TEN-00211	ENSTNIG00000005453	PRKCB (1 of 2)
8		EKS-TEN-00216	ENSTNIG00000014911	PRKCI
9		EKS-TEN-00221	ENSTNIG00000014600	PRKCD (2 of 3)
10		EKS-TEN-00213	ENSTNIG00000014129	PRKCA (1 of 2)
11		EKS-TEN-00218	ENSTNIG00000008102	PRKCG
12		EKS-TEN-00224	ENSTNIG00000011612	PRKCB (2 of 2)
13		EKS-TEN-00222	ENSTNIG00000011122	PRKCD (3 of 3)
14		EKS-TEN-00223	ENSTNIG00000003227	PRKCD (1 of 3)