Macaca mulatta      Atypical      ABC1

※ ABC1 family introduction

    ABC1 kinases are family of aarF domain-containing protein kinases which belong to atypical kinase group. Five members have been identified in human genome, known as ADCK1-ADCK5. ABC1 kinases contain the conserved protein kinase motifs which is responsible for the ATP binding and phosphotransfer reaction. However, as the overall sequence is distinct with ePK domain and lack of several usual kinase motifs, they are classified into "Atypical" kinase group (1).

Reference
1. Lagier-Tourenne, C., Tazir, M., Lopez, L.C., Quinzii, C.M., Assoum, M., Drouot, N., Busso, C., Makri, S., Ali-Pacha, L., Benhassine, T. et al. (2008) ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Am J Hum Genet, 82, 661-672. PMID: 18319074


There are 5 genes.  Reviewed (0 or Unreviewed (5

No.StatusEKPD IDGene IDGene Name
1
EKS-MAM-00132
ENSMMUG00000004228
ADCK4; EGK_10633
2
EKS-MAM-00131
ENSMMUG00000008636
EGK_01588; CABC1; ADCK3
3
EKS-MAM-00130
ENSMMUG00000023627
ADCK1; EGK_18427
4
EKS-MAM-00134
ENSMMUG00000015282
ADCK2
5
EKS-MAM-00133
ENSMMUG00000007376
ADCK5