※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase

  Reviewed (7)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-CAE-00390	F09C12.2	F09C12.2
2		EKS-CAE-00397	K11H12.9	K11H12.9
3		EKS-CAE-00386	B0478.1	B0478.1; jnk-1
4		EKS-CAE-00383	F42G8.3	pmk-2; F42G8.3
5		EKS-CAE-00393	F42G8.4	pmk-3; F42G8.4
6		EKS-CAE-00392	ZC416.4	CELE_ZC416.4; kgb-2
7		EKS-CAE-00388	T07A9.3	kgb-1; CELE_T07A9.3
8		EKS-CAE-00389	W06F12.1	W06F12.1; nlk; lit-1
9		EKS-CAE-00395	C49C3.10	C49C3.10, CELE_C49C3.10; C49C3.10
10		EKS-CAE-00385	F43C1.2	F43C1.2; sur-1; mpk-1
11		EKS-CAE-00387	C04G6.1	mpk-2
12		EKS-CAE-00394	W06B3.2	sma-5
13		EKS-CAE-00391	C05D10.2	C05D10.2
14		EKS-CAE-00384	B0218.3	pmk-1; B0218.3
15		EKS-CAE-00396	Y51B9A.9	Y51B9A.9; CELE_Y51B9A.9, Y51B9A.9