※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase

  Reviewed (2)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAG-00389	ENSGALG00000001501	MAPK1
2		EKS-GAG-00387	ENSGALG00000013761	JNK2; MAPK9
3		EKS-GAG-00383	ENSGALG00000019759	MAPK14
4		EKS-GAG-00388	ENSGALG00000006109	MAPK8
5		EKS-GAG-00392	ENSGALG00000004690	MAPK6; RCJMB04_5i17
6		EKS-GAG-00390	ENSGALG00000004967	MAPK15
7		EKS-GAG-00391	ENSGALG00000005699	NLK
8		EKS-GAG-00386	ENSGALG00000011109	MAPK10
9		EKS-GAG-00384	ENSGALG00000008612	MAPK11
10		EKS-GAG-00385	ENSGALG00000000826	MAPK13