※ MAPK family introduction

    MAPK (mitogen-activated protein kinase) are serine/threonine specific protein kinases belonging to CMGC kinase group. MAPKs play an important role in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. MAPKs are involved in regulation of a variety of cellular processes, including cell proliferation, gene expression, differentiation, mitosis, cell survival and cell apoptosis. Three subfamilys constitute MAPK family, extracellular-receptor kinases (ERK), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) and p38 MAPKinases. MAPK signaling pathways are important in animals, fungi and plants. ERK1/2 pathway is best understood in animals, which is essential for cell proliferation and cell cycle. Fus3 pathway is also well studied in fungi, which is responsible for cell cycle and mating in responses to pheromone stimulation. MAPKs pathway in plants may response to osmotic shock, oxidative stress, cold and anti-pathogen responses (1).

Reference
1. Wikipedia Annotation:    Mitogen-activated protein kinase

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GOG-00457	ENSGGOG00000006045	MAPK7
2		EKS-GOG-00461	ENSGGOG00000024016	ENSG00000215179
3		EKS-GOG-00452	ENSGGOG00000016519	MAPK9
4		EKS-GOG-00450	ENSGGOG00000011613	MAPK1
5		EKS-GOG-00451	ENSGGOG00000003947	MAPK13
6		EKS-GOG-00455	ENSGGOG00000011771	MAPK8
7		EKS-GOG-00458	ENSGGOG00000007904	MAPK15
8		EKS-GOG-00453	ENSGGOG00000003141	MAPK10
9		EKS-GOG-00454	ENSGGOG00000027293	MAPK11
10		EKS-GOG-00460	ENSGGOG00000010469	MAPK4
11		EKS-GOG-00456	ENSGGOG00000008951	MAPK3
12		EKS-GOG-00459	ENSGGOG00000004003	MAPK6
13		EKS-GOG-00462	ENSGGOG00000026501