※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (0)  or Unreviewed (15) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-AIM-00014	ENSAMEG00000018774	DUSP14; PANDA_014347
2		EPS-AIM-00022	ENSAMEG00000000368	RNGTT
3		EPS-AIM-00021	ENSAMEG00000015677	DUSP23
4		EPS-AIM-00008	ENSAMEG00000001742	DUPD1
5		EPS-AIM-00010	ENSAMEG00000001730	DUSP13
6		EPS-AIM-00015	ENSAMEG00000018304	DUSP3
7		EPS-AIM-00011	ENSAMEG00000019469	DUSP21
8		EPS-AIM-00013	ENSAMEG00000000020	DUSP27
9		EPS-AIM-00016	ENSAMEG00000005967	DUSP22
10		EPS-AIM-00012	ENSAMEG00000007390	DUSP18
11		EPS-AIM-00009	ENSAMEG00000008481	PANDA_021554; DUSP26
12		EPS-AIM-00020	ENSAMEG00000003057
13		EPS-AIM-00017	ENSAMEG00000006050	EPM2A
14		EPS-AIM-00019	ENSAMEG00000007624	PTPMT1
15		EPS-AIM-00018	ENSAMEG00000017403	PANDA_010433; DUSP11