※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-CAP-00011	ENSCPOG00000013650	DUSP22
2		EPS-CAP-00012	ENSCPOG00000001290	DUSP12
3		EPS-CAP-00004	ENSCPOG00000001385	DUSP21
4		EPS-CAP-00007	ENSCPOG00000026302	DUSP3
5		EPS-CAP-00002	ENSCPOG00000022980	DUPD1
6		EPS-CAP-00003	ENSCPOG00000001441	DUSP26
7		EPS-CAP-00017	ENSCPOG00000005124	RNGTT
8		EPS-CAP-00008	ENSCPOG00000002322	DUSP27
9		EPS-CAP-00014	ENSCPOG00000002055	EPM2A
10		EPS-CAP-00013	ENSCPOG00000022539	DUSP11
11		EPS-CAP-00006	ENSCPOG00000006560	DUSP13
12		EPS-CAP-00016	ENSCPOG00000025987	DUSP23
13		EPS-CAP-00005	ENSCPOG00000003670	DUSP18
14		EPS-CAP-00015	ENSCPOG00000024955	PTPMT1
15		EPS-CAP-00010	ENSCPOG00000009022	DUSP15
16		EPS-CAP-00009	ENSCPOG00000004638	DUSP14