※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (1)  or Unreviewed (14) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-GAG-00017	ENSGALG00000021017	DUSP15
2		EPS-GAG-00008	ENSGALG00000005019	DUPD1
3		EPS-GAG-00010	ENSGALG00000005017	DUSP13
4		EPS-GAG-00011	ENSGALG00000005007
5		EPS-GAG-00018	ENSGALG00000005754	LOC768665
6		EPS-GAG-00012	ENSGALG00000007765	DUSP18
7		EPS-GAG-00015	ENSGALG00000009931	DUSP3
8		EPS-GAG-00014	ENSGALG00000005455	DUSP14
9		EPS-GAG-00013	ENSGALG00000015453	DUSP27
10		EPS-GAG-00021	ENSGALG00000012275	EPM2A; RCJMB04_7n21; Epm2a
11		EPS-GAG-00009	ENSGALG00000001633	DUSP26
12		EPS-GAG-00020	ENSGALG00000007084	DUSP12
13		EPS-GAG-00022	ENSGALG00000020775	DUSP11
14		EPS-GAG-00019	ENSGALG00000000399	DUSP28
15		EPS-GAG-00016	ENSGALG00000012829	DUSP22