※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-LOA-00013	ENSLAFG00000009613	EPM2A
2		EPS-LOA-00002	ENSLAFG00000021406	DUPD1
3		EPS-LOA-00012	ENSLAFG00000005550	DUSP12
4		EPS-LOA-00010	ENSLAFG00000018297	DUSP22
5		EPS-LOA-00016	ENSLAFG00000014105	DUSP23
6		EPS-LOA-00008	ENSLAFG00000018677	DUSP27
7		EPS-LOA-00004	ENSLAFG00000026669	LOC100667207
8		EPS-LOA-00015	ENSLAFG00000020874	PTPMT1
9		EPS-LOA-00014	ENSLAFG00000001637	DUSP11
10		EPS-LOA-00003	ENSLAFG00000000679	DUSP26
11		EPS-LOA-00005	ENSLAFG00000007621	DUSP18
12		EPS-LOA-00007	ENSLAFG00000016354	DUSP3
13		EPS-LOA-00009	ENSLAFG00000002632	DUSP14
14		EPS-LOA-00011	ENSLAFG00000013638	DUSP15
15		EPS-LOA-00006	ENSLAFG00000021812	DUSP21